Atheroprotective effects of lymphotoxin beta receptor deletion in ApoE-deficient mice
نویسندگان
چکیده
منابع مشابه
Deficiency in lymphotoxin β receptor protects from atherosclerosis in apoE-deficient mice.
RATIONALE Lymphotoxin β receptor (LTbR) regulates immune cell trafficking and communication in inflammatory diseases. However, the role of LTbR in atherosclerosis is still unclear. OBJECTIVE The aim of this study was to elucidate the role of LTbR in atherosclerosis. METHODS AND RESULTS After 15 weeks of feeding a Western-type diet, mice double-deficient in apolipoprotein E and LTbR (apoE(-/...
متن کاملMolecular Medicine Genetic Deletion of Chemokine Receptor Ccr6 Decreases Atherogenesis in ApoE-Deficient Mice
Objective: Our objective was to delineate the role of Ccr6 in atherogenesis in the apolipoprotein E–deficient (ApoE / ) mouse model of atherosclerosis. Methods and Results: Both Ccr6 and Ccl20 are expressed in atherosclerotic aorta from ApoE / mice. Aortic lesion area in Ccr6 / ApoE / mice was 40% and 30% smaller than in Ccr6 / ApoE / mice at 16 and 24 weeks of age, respectively. Transplantatio...
متن کاملGenetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice.
RATIONALE The chemokine receptor Ccr6 is a G-protein-coupled receptor expressed on various types of leukocytes identified in mouse atherosclerotic lesions. Recent evidence suggests that both CCR6 and its ligand CCL20 are also present in human atheroma; however, their functional roles in atherogenesis remain undefined. OBJECTIVE Our objective was to delineate the role of Ccr6 in atherogenesis ...
متن کاملGenetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
AIMS Recent evidence suggests that both Ccr7 and its ligands, Ccl19 and Ccl21, are present in mouse and human atherosclerotic plaques; however, the role of Ccr7 in atherogenesis is still controversial. Here, we addressed this question by using the classic apolipoprotein E-deficient (ApoE(-/-)) mouse model of atherosclerosis. METHODS AND RESULTS Ccr7(-/-)ApoE(-/-) double knockout mice and Ccr7...
متن کاملComplete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice[S]
Cd39 scavenges extracellular ATP and ADP, ultimately generating adenosine, a nucleoside, which has anti-inflammatory effects in the vasculature. We have evaluated the role of Cd39 in the development of atherosclerosis in hyperlipidemic mice. ApoE KO (Cd39+/+/ApoE-/-) and Cd39/ApoE double KO (DKO) (Cd39-/-/ApoE-/-) mice were maintained on chow or Western diet for up to 20 weeks before evaluation...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2013
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/eht308.p2385